Like every other cell in our body, the reproductive cells also lose their best potential as we age. Irrespective of other associated factors, the fertility potential of both men and women decreases with age.
Patient information by American society of Reproductive medicine 2012 Click here
Considering these factors, it may be safe to say that fertility evaluation is best done earlier than later. If you choose to postpone conception, the choice of oocyte or embryo cryopreservation maybe opted for.
Empty follicle syndrome (EFS), is an extremely rare (incidence of 0.2–7% of all IVF cycles) condition where no oocytes are retrieved during in vitro fertilization (IVF), even though ultrasound and estradiol values show the presence of many potential mature follicles.
It is important for us to differentiate a true empty follicle syndrome from that of an iatrogenic one resulting from improper action of the medication (trigger). In the later case, women may be re-stimulated for IVF and there is a good chance of obtaining mature oocytes and result in pregnancy using their biological (self) oocytes. However, in true EFS, there is no benefit of doing a repeat stimulation.
Unfortunately there are no methods to predict EFS. It is diagnosed only on the day of egg pick up.
The only solace is that, the condition is indeed extremely rare.